Tianeptine is a drug used for treating depression, sold under the brand names Stablon, Coaxil and Tatinol. It is viewed as one of the most effective treatments for major depressive episodes that range from mild to severe.
Tianeptine has also been used as an off-label nootropic agent and is reported to produce sensations of wellbeing, optimizing and mental clarity. The drug is marketed as having mood brightening effects as well as being neuroprotective and anxiolytic (reducing anxiety).
It is currently approved for this use in France and a number of other countries, especially throughout the European Union. It was developed at the French Society of Medical Research in the 1960’s. Because the early research was all in French, this seems to have delayed Tianeptine’s acceptance in a number of English-speaking countries.
Tianeptine is a selective Serotonin re-uptake enhancer (SSRE). This is basically a tricyclic type of anti-depressant which contains three rings of atoms in its chemical structure.
What this drug does is to enhance the re-uptake or re-absorption of Serotonin once it has been released by your neurons. This takes the Serotonin out of circulation, removing it from contact with synaptic receptors.
What is interesting is that its mechanism of action is directly opposite to how most currently prescribed anti-depressant medications work.
Independant Information about Stablon (Tianeptine)
BlueLight Discussion - Online discussion on various medications
Drug Forums - Recreational Usage of Tianeptine
Reddit Users - Tianeptine discussion
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Interest in Tianeptine has grown substantially in recent years.
In this guide we’ll weigh the benefits of Tianeptine against the risks, discuss the best practices for using Tianeptine, Tianeptine vendors, and finally compare Tianpetine sodium to Tianeptine
Is the Hype About Tianeptine Justified?
Well, it depends. If you’re a perfectly healthy, well-adjusted 18-30 year old with no family history of mental illness, probably not. But if you’ve ever had a mood disorder or struggled with anxiety, Tianeptine is absolutely all it’s cracked up to be.
This reflects a general trend with
What is Tianeptine, Anyway?
What Does Tianeptine Do?
It does a lot of stuff, neurotransmitter-wise. It binds and activates mu-opioid receptors (the same receptors affected by painkillers). It was thought to clear serotonin from the synapse (“selective-serotonin re-uptake enhancement”). This view has mostly been rescinded. If Tianeptine does promote serotonin clearance at all, this effect is weak and doesn’t contribute to Tianeptine’s efficacy as an antidepressant.
There’s sparse evidence to support this, but my view is that Tianeptine reproduces the beneficial effects of exercise on cognition. To oversimplify, the “runner’s high” is probably caused by the release of natural opioids, like
There are some other similarities between exercise and Tianeptine. Both “reverse stress-induced synaptic remodeling and impaired
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